After leaving the soap opera Donna headed to Hollywood where, in 1970 she made a guest starring performance in the Burt Reynolds crime show ‘Dan August’. But her best known role to date was when she was cast in the film role of the DJ’s girlfriend, Tobie, opposite Clint Eastwood in ‘Play Misty for Me’, in 1971. Mills appeared in numerous made for TV movies through the 1970s such as ‘The Six Million Dollar Man’ with Lee Majors and Lindsay Wagner, ‘The Love Boat’ which starred many up and coming celebrities such as Courteney Cox and some older stars such as Danny Bonaduce. She made appearances in several soap operas including ‘Melrose Place’ with Kristin Davis, and more recently in the crimes revisited series, ‘Cold Case’.

The 1980’s saw Donna in the role of Abby Cunningham, the calculating vixen in the long running series ‘Knots Landing’, alongside Ted Shackelford and Joan Van Ark. The role brought Mills three Soap Opera Digest Awards.

Mills' friend, Larry Hagman, with whom she had once starred with in ‘The Good Life’ made appearances with her and the cast of Knots Landing for four episodes, in which they conspired together to cause trouble as both of their characters were well known for doing. She returned for the series finale in 1993 and the reunion movie Knots Landing: Back to the Cul-de-Sac in 1997.

She has since gone on to headline a number of TV-movies, frequently also serving as executive producer for such telepics as ‘Runaway Father’ in 1991, ‘In My Daughter’s Name’ in 1992 and ‘My Name Is Kate’ in 1994.